TRATAMIENTO DE TINEA UNGUIS CON LAMISIL: EXPERIENCIA EN VENEZUELA

Resumen

En estudio simple, abierto, multicéntrico, se enrolaron 93
pacientes (43 varones y 48 mujeres) mayores de 18 años
con tinea unguis de pies, quienes recibieron terbinafina
(Lamisil), 250 mg diarios por 90 días. De ellos se aislaron 71
cepas de Trichophyton rubrum, 21 de Tr. mentagrophytes y 1
de Epidermophyton floccosum. Al término de la medicación
(3 meses), se presentaron 67 pacientes, 65 de lo cuales
(96,5%) resultaron negativos al examen micológico. A los 3
meses de seguimiento, un paciente más resultó negativo. A
los 6 meses de seguimiento, se registró recaída. Cuatro
pacientes mostraron leves efectos secundarios adversos;
dos de ellos se retiraron del estudio. En conclusión,
pensamos que, bajo las condiciones del presente ensayo, la
terbinafina (Lamisil) ha mostrado rápida e intensa actividad y
alta tolerabilidad.
ABSTRACT
In a simple, open, multicentric study, 93 patients (45 males
and 48 females) 18 years old and up, with podal tinea unguis,
received terbinafine (Lasimil) per os, 250 mg per day during
90 days. By culture, 71 strains of Trichophyton rubrum, 21 of
Tr. mentagrophytes and 1 of Epidermophyton floccosum were
isolated. A the end of the medication period (3 months), 65 of
67 patients had negative results. After 3 months of follow up,
another patient became negative totalling 97% negative
mycological results. After 6 months of follow up, one relapse
was discovered. In 4 patients, light adverse secondary effects
were noted; two patients were drop out from the study owing
to this. In conclusion, we think that, under the conditions of
the present study, terbinafine (Lamisil) showed a rapid and
strong effectiveness and a high tolerability.