Antioxidantes como compuestos quimiopreventivos del cáncer cutáneo.

Franklin Ramon Vargas Tovar; Miguel D. León.; María G. Herrera; Emily C.  Acevedo.; Valery  John.

Autores/as

Franklin Ramon Vargas Tovar Instituto Venezolano de Investigaciones Científica IVIC https://orcid.org/0000-0001-8170-7793
Miguel D. León. Laboratorio de Fotoquímica, Instituto Venezolano de Investigaciones Científicas I.V.I.C. https://orcid.org/0009-0001-1108-433X
María G. Herrera Laboratorio de Fotoquímica, Instituto Venezolano de Investigaciones Científicas I.V.I.C. https://orcid.org/0000-0003-4411-0060
Emily C. Acevedo. Laboratorio de Fotoquímica, Instituto Venezolano de Investigaciones Científicas I.V.I.C. https://orcid.org/0009-0007-3733-0168
Valery John. Laboratorio de Química Analítica, Centro de Química “Dr. Gabriel Chuchani”, Instituto Venezolano de Investigaciones Científicas I.V.I.C. https://orcid.org/0009-0005-4507-9474

Palabras clave:

antioxidantes, cáncer, especies reactivas de oxígeno, piel, radicales libres, quimioprevención.

Resumen

En esta revisión se presentan los estudios realizados de ciertos antioxidantes utilizados para prevenir el cáncer de piel. Se destaca las diferentes rutas y mecanismos de acción sobre este órgano y sus componentes celulares, las formas de ingreso, vía ingesta, disposición alimentaria, y tópica. Se describe en cuales etapas, iniciación, promoción y/o progresión del cáncer son efectivas como moduladores de los sistemas de protección celular frente a radicales libres y especies reactivas de oxígeno.

Palabras claves: antioxidantes; cáncer; especies reactivas de oxígeno; piel; radicales libres; quimioprevención.

Biografía del autor/a

Franklin Ramon Vargas Tovar, Instituto Venezolano de Investigaciones Científica IVIC

Investigador Titular, Jefe del laboratorio de Fotoquímica, Centro de Química

Referencias

Hamid A, Aiyelaagbe O, Usman L, Ameen O, Lawal A. Antioxidants: Its medicinal and pharmacological applications. African J. Pure Appl. Chem. 2010;4(8):142-51.

Katiyar S, Ahmad N, Mukhtar H. Green tea and skin. Arch. Dermatol. 2000; 136:989-94.

Stoner GD, Mukhar H. Polyphenols as cáncer chemopreventive agents. J. Cell Biochem. 1995;22:169-80.

Silva VO, Freitas AA, Maçanita AL, Quina FH. Chemistry and photochemistry of natural plant pigments: The anthocyanins. J. Phys. Org. Chem. 2016;29(11):594-99.

Diaconeasa Z, Știrbu I, Xiao J, Leopold N, Ayvaz Z, Danciu C. Anthocyanins, vibrant color pigments, and their role in Skin cancer prevention. Biomed. 2020;8(9):336-76.

Huang MT, Newmark HI, Frenkel K. Inhibitory effects of curcumin on tumorigenes in mice. J. Cell Biochem. 1997;27:26-34.

Tarocco A, Caroccia N, Morciano G, Wieckowski MR, Ancora G, Garani G, Pinton P. Melatonin as a master regulator of cell death and inflammation: molecular mechanisms. Cell Death & Disease, 2019;10:317.

Ferlazzo N, Andolina G, Cannata A, Costanzo MG, Rizzo V, Currò M, Lentile R, Caccamo D. Is Melatonin the Cornucopia of the 21st Century. Antioxidants, 2020;9(11):1088.

Cagnoli CM, Atabay C, Kharlamova E, Manev H. Melatonin protects neurons from singlet oxygen induced apoptosis. J. Pineal Res. 1995;18:222-26.

Pieri C, Marra M, Moroni F, Recchioni R, Marcheselli F. Melatonin: A peroxyl radical scavenger more effective than vitamin E. Life Sci. 1994;55:271-76.

Princ FG, Maxit AG, Cardalda C, Batle A, Juknat AA. In vivo protection by melatonin against delta-aminolevulinic acid-induced oxidative damage and its antioxidant effect on the activity of haem cnzymes. J. Pineal Res. 1998;24:1-8.

Fischer T, Scholz G, Knöll B, Hipler UC, Elsner P. Effect of melatonin as a radical scavenger on UV-irradiated, IIL-3-stimulated leucocytes. Arch. Dermatol. Res. 1999;291:141.

Fischer TW, Scholz G, Knöll B, Hipler UC, Elsner P. Efficacy of melatonin compared to vitamin C and trolox as radical scavengers in UVB-irradiated, IL-3- stimulated leucocytes. Arch. Dermatol. Res. 2000;292:101.

Lemmo W. Potential interactions of prescription and over-the-counter medications having antioxidant capabilities with radiation and chemotherapy. Int. J. cancer, 2015;13(11):2525-533.

Fortmann SP, Burda BU, Senger CA, Lin JS. Vitamin and mineral supplements in the primary prevention of cardiovascular disease and cancer: an updated systematic evidence review for the US Preventive Services Task Force. Ann. Intern. Med. 2013;159(12):824-34.

Biesalski HK, Frank J. Antioxidants in nutrition and their importance for the anti- prooxidative balance in the immune system. Immun. Infekt. 1995;23(5):166-73.

Yusuf S, Dagenais G, Pogue J, Bosch J. Vitamin E supplementation and cardiovascular events in high-risk patients. N. Engl. J. Med. 2000;342(3):154-60.

Michels AJ. Artifacts, and fatal flaws: identifying limitations and opportunities in vitamin C research. Nutrients. 2013;5(12):5161-192.

Combs GF, McClung JM. The vitamins: fundamental aspects in nutrition and health. U.S.A.: Acad. Press; 2016. p. 1-628.

Padayatty SJ, Katz A, Wang Y, Eck P, Kwon O, Lee JH. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J. Am. Coll. Nutr. 2003;22(1):18-35.

Cortés-Jofré M, Rueda JR, Corsini-Muñoz G, Fonseca-Cortés C, Caraballoso M. Drugs for preventing lung cancer in healthy people. Cochrane Database Syst. Rev. 2012;10.

Ye Y, Li J, Yuan Z. Effect of Antioxidant Vitamin Supplementation on Cardiovascular Outcomes: A Meta-Analysis of Randomized Controlled Trials. PLoS One. 2013;8(2):1.

Krinsky NI, Beecher GR, Burk RF, Chan AC, Erdman JJ, Jacob RA, Jialal I, Kolonel LN, Marshall JR. Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Inst. Med. 2000;19:95-185.

Bellows L, Moore R. Water-Soluble Vitamins: B-Complex and Vitamin C, Food Nutr. Ser. Heal. 2012;9312.

Thomas LD, Elinder CG, Tiselius HG, Wolk A. Ascorbic acid supplements and kidney stone incidence among men: a prospective study. JAMA Intern. Med. 2013;173(5):386-88.

Khadim RM, Al-Fartusie FS. Antioxidant vitamins and their effect on immune system. J. Phys.: Conf. Ser. 2021;1853:012065.

Solomon NW. Vitamin A. En: Erdman J W, MacDonald I A, Zeisel S H, Editors. Present knowledge in nutrition. U.S.A.: Wiley; 2012. p. 149-84.

Rezaieyazdi Z, Sahebari M, Saadati N. Vitamin E and Autoimmune Diseases: A Narrative Review. Rev. Clin. Med. 2018;5(2):42-48.

Villamor E. Effects of vitamin A supplementation on immune responses and correlation with clinical outcomes, Clin. Microbiol. Rev. 2005;18(3):446-64.

Huang Z, Liu Y, Qi G, Brand D. Role of vitamin A in the immune system. J. Clin. Med. 2018;7(9):258.

Minoch R, Damian DL, Halliday GM, Minocha R. Melanoma and

nonmelanoma skin cancer chemoprevention: A role for nicotinamide. Photodermatol.Photoimmunol. Photomed. 2018;34(1):5-12.

Giacalone S, Spigariolo CB, Bortoluzzi P, Nazzaro G, Giacalone S. Oral

nicotinamide: The role in skin cancer chemoprevention. Dermatol. Ther. 2021;34(3):e14892.

Wei H, Saladi R, Lu Y, Wang Y, Palep S, Moore J. Isoflavone genistein:photoprotection and clinical implications in dermatology. J. Nutr. 2003;133:3811S-

S.

Vargas F, Díaz Y, Carbonell K. Antioxidant and scavenging activity of emodin, aloe-emodin and rhein on free radical and reactive oxygen species. Pharm. Biol. 2004; 42(4-5):342-48.

Vargas F, Rivas C, Medrano M. Interaction of Emodin, Aloe-emodin and Rhein with Human Serum Albumin. A Fluorescence Spectroscopic Study. Toxicol. Mech. Methods. 2004;14(4):227-31.

Vargas F, Rivas C, Díaz Y, Carbonell K, Zoltan T, Fraile G, Velásquez M. Antioxidant properties of hydroxyanthraquinone (Aloe vera-derivate). En: Govil JN, editors. Recent Progress in Medicinal Plants, U.S.A.: Studium Press LLC; 2005. p. 147-58.

Vargas F, Rivas C, Zoltan T, López V, Ortega J, Izzo C, Pineda MF, Medina JD, Medina E, Rosales LE. Antioxidant and Scavenging Activity of Skyrin on Free Radical and some Reactive Oxygen Species. Av. Quím. 2008;3(1):7-14.

Davinelli S, Nielsen M, Scapagnini G. Astaxanthin in skin health, repair, and disease: A comprehensive review. Nutrients. 2018;10(4):522-34.

Antioxidantes como compuestos quimiopreventivos del cáncer cutáneo.

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